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(A) Chemical structures of the NSD2 PROTAC degrader 9 (top), and its negative controls 17 (middle) and 18 (bottom). The yellow ellipse highlights the groups changed from 9. (B-E) Inverse ITC titrations of the NSD2 PWWP1 domain into UNC6934 (B), 9 (C), 17 (D), and 18 (E). The calculated binding affinity values represent the mean ± SD from two independent experiments. The first injection has been removed from the fitting.
