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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: J Med Chem. 2022 Jul 27;65(15):10611–10625. doi: 10.1021/acs.jmedchem.2c00807

Figure 6.

Figure 6.

Compound 9 reduces the protein levels of NSD2, IKZF1, and IKZF3, but not GSPT1, while compound 18 degrades IKZF1 and IKZF3 but not NSD2 and GSPT1, and compound 17 and UNC6934 do not degrade any of these proteins, in KMS11 (A) and H929 (B) cells. The cells were treated with DMSO or 2.5 μM of the indicated compound for 72 h. The protein levels were detected by Western blotting with GAPDH as the loading control. The Western blotting results are representative of two independent experiments.