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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: J Med Chem. 2022 Jul 27;65(15):10611–10625. doi: 10.1021/acs.jmedchem.2c00807

Figure 7.

Figure 7.

(A) Compound 9 reduces the IKZF3 protein level in 293FT cells in a proteasome-dependent manner. 293FT cells were pretreated with DMSO, 10 nM of MLN9708 or 0.5 μM of MLN4924 for 2 h, followed by a 6 h treatment with 5 μM of compound 9. (B) Compound 9 reduces the IKZF1 and IKZF3 protein levels in KMS11 cells in a proteasome-dependent manner. KMS11 cells were pretreated with DMSO, 10 nM of MLN9708 or 0.5 μM of MLN4924 for 2 h, followed by a 6 h treatment with 5 μM of compound 9. The IKZF1 and IKZF3 protein levels were detected by Western blotting with GAPDH as the loading control. The WB results are representative of at least two independent experiments.