Table 2.

Association between Clinical and Demographic Characteristics and Time to Schwannomatosis Diagnosis

	Time to Diagnosis Communicated (n=54)	Total Time in the Diagnostic Process† (n=97)
Sex	5.77 vs. 9.87	6.29 vs 10.01
Female vs. Male	U=257, p=0.06	U=934.5, p=0.08
Inheritance Pattern	8.00 vs. 5.87	9.05 vs. 5.86
Sporadic vs. Familial	U=151, p=0.44	U=484.5, p=0.193
Extent of Disease	6.83 vs. 8.45	7.86 vs 9.23
Full vs. Anatomically Limited	U=198, p=0.41	U=704, p=0.56
Age at First Symptom	Rho = −0.31 p=0.02	Rho = −0.39 p<0.001
Initial Symptom Type ‡	4.77 vs. 3.46 vs. 8.32	4.64 vs. 5.86 vs. 9.87
Asymptomatic vs. Palpable Mass vs.	H(2)=8.44, p=0.02	H(2)=10.79, p=0.005
Other Symptoms
Initial Symptom Frequency	4.77 vs. 4.00 vs. 8.58 vs. 10.98	4.64 vs. 5.84 vs. 9.74 vs. 11.95
Asymptomatic vs. Constant vs.	H(3)=14.69, p=0.002	H(3)=16.79, p=0.001
Intermittent vs. Unknown
Initial Imaging Presentation §	8.32 vs. 5.63	9.19 vs. 6.61
Single Tumor vs. Multiple Tumors	U=810.5, p=0.04	U=229, p=0.04

For categorical variables, median diagnostic interval length is reported in years. Test statistics and p-values are reported using Mann Whitney U (for dichotomous variables), Kruskal-Wallis H test (for other categorical variables), and Spearman’s Rho (for continuous variables).

^†Time spent in the diagnostic process extends to the time a diagnosis was communicated, or if that did not occur, the time of the person’s last follow-up in NF clinic.

^‡“Palpable mass” includes mass with or without additional symptoms; “other symptoms” includes pain, neurological symptoms or severe coughing spells only; and 2 people with unknown symptoms were excluded from analysis.

^§Three people with either zero or an unknown number of tumors were excluded from analysis.