Figure 7.

Inhibition of human I_CatSper by compounds from each hit series. A. Representative I_CatSper recording from human sperm in cesium divalent free media (CsDVF) elicited by the voltage ramp in the absence (black) and presence (purple) of test compound 2 a. Baseline signal in high saline (HS) buffer shown in grey. B. Current density plots of tested compounds showing inhibition of I_CatSper at +80 mV (positive scale) or −80 mV (negative scale). Data are displayed as means±SEM of at least 3 independent experiments.