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Activity and cytotoxicity of seven potent compounds from each hit series and two reference compounds. Activity is expressed as the percent of control calcium‐dependent fluorescence elicited by progesterone and high potassium‐induced activation of CatSper in human sperm. Cytotoxicity indicated by the reduction in viability of in both human sperm and IMR‐90 fibroblasts using the AlamarBlue assay.
