Table 8.
Cytotoxicity profiling of most potent hits and reference compounds.[a]
|
Compound |
Cytotoxicity: IC50 [μM] |
|
|---|---|---|
|
Sperm |
IMR‐90 |
|
|
Mibefradil |
25±2 |
22±1 |
|
NNC 55–0396 |
62±21 |
13±2 |
|
1 a |
>100 |
>100 |
|
2 a |
>100 |
>100 |
|
3 a |
>100 |
96±5 |
|
4 a |
>100 |
>100 |
|
5 f |
>100 |
83±14 |
|
6 b |
84±10 |
68±5 |
|
7 a |
>100 |
>100 |
[a] Cytotoxicity was measured using AlamarBlue fluorescence. IC50 values are the mean±SEM of three independent experiments. *Compounds increased fluorescence at higher concentrations.