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. 2022 Aug 15;12:11763. doi: 10.1038/s41598-022-15911-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PPI network analysis for affected genes when TRIM31 was silenced in 20 CRC cell lines using rnai. while upregulated genes with red circles exhibited weak co-expression score (less than 0.5), blue circles indicating downregulated genes showed co-expression score bigger than 0.5 (a). Blue circles exhibiting downregulated genes are highlighted with red coloured text exhibited 18 nodes indicating similar processes using gene ontology analysis (b). The 18 nodes indicating cellular processes that mostly affected by TRIM31 silencing are presented by the names of these proteins and their cellular function such as viral transcription & viral processes, RNA binding, and ribosome small subunit biogenesis are listed (c). Majority of these cellular processes that are affected by TRIM31 silencing in crc cell lines are related to viral transcription & viral processes.