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. 2022 Aug 15;13:4770. doi: 10.1038/s41467-022-32307-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Mean±SEM changes in sedentary time from week −8 to week 0 (low-calorie diet, yellow color in grey shaded area, n = 130) for all groups combined and from week 0 to week 52 (after randomization) in the four groups, separately: placebo (grey color, n = 39), exercise (green color, n = 26), liraglutide (blue color, n = 36), and the combination of liraglutide and exercise (red color, n = 29). Means were estimated from a mixed model analysis as described in statistical analyses. Results are presented for study participants who adhered to the study interventions (per protocol population). Sedentary time was measured with wrist-worn accelerometry. b Violin plots of observed changes in sedentary time the low-calorie diet and for all groups, separately. The diamonds indicate observed means and the dots indicate individual observations. Results are presented for the per protocol population (n = 130). P values are provided for significant (P < 0.05) differences from the placebo group. P-values are two-sided and unadjusted for multiple comparisons and derived from a mixed model analysis as described in statistical analyses. Source data are provided as a Source Data file.