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. 2022 Aug 15;13:4770. doi: 10.1038/s41467-022-32307-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Weekly energy expended during exercise (kcal/week), b weekly exercise duration (min/week), and c weekly exercise intensity (percentage of maximum heart rate) from the first week after randomization (week 1) throughout the one-year intervention period in the two groups that included an exercise intervention: exercise (green color, n = 26) and the combination of exercise and liraglutide (red color, n = 29). The exercise program consisted of a gradual increase from week 1 to 6 after which the exercise program was fully implemented. Plotted values are observed means for study participants who adhered to the study interventions (per protocol population). Source data are provided as a Source Data file.