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. Author manuscript; available in PMC: 2023 Aug 16.
Published in final edited form as: Circulation. 2022 Jun 27;146(7):548–564. doi: 10.1161/CIRCULATIONAHA.121.058607

Fig. 7. PKCα:TRPV4SMC co-localization is increased and TRPV4SMC:BK co-localization is reduced in hypertension.

Fig. 7.

(A) Representative in situ PLA images showing SMC nuclei (blue), TRPV4SMC:PKCα and TRPV4SMC:BK co-localization (white puncta) in en face preparations of MAs from Ang II-induced hypertensive mice and non-hypertensive control mice. (B) Quantification of TRPV4SMC:PKCα (Control, n = 6; Hypertension, n = 6) and TRPV4SMC:BK co-localization (Control, n = 6; Hypertension, n = 6) co-localization in MAs from Ang II-induced hypertensive mice and control mice (***P < 0.001 vs. Control; unpaired t-test). (C) Representative in situ PLA images showing SMC nuclei (blue), TRPV4SMC:PKCα and TRPV4SMC:BK co-localization (white puncta) in en face preparations of paraspinal muscle arteries from non-hypertensive (control) and hypertensive individuals. (D) Quantification of TRPV4SMC:PKCα (Control, n = 6; Hypertension, n = 6) and TRPV4SMC:BK (Control, n = 6; Hypertension, n = 6) co-localization in paraspinal muscle arteries from non-hypertensive (control) and hypertensive individuals (*P < 0.05 vs. Control; unpaired t-test).