FIG. 2.

Alignment of the B. subtilis YtvP (HisJ) protein (BSUB; accession no. PIR:D70002), the S. cerevisiae His9p HolPase (SCER; accession no. PIR:S56280), and the presumed HolPases L. lactis ORF13 gene product (LLAC; accession no. PIR:D47754) and S. pombe His9p homologue (SPOM; accession no. SPTREMBLNEW:E1316727). Residues conserved (identity and conservative change) in at least two of these proteins are against a black background (residues conserved in YtvP) or a grey background (residues not conserved in YtvP); groups of conservative change considered are G and A; D and E; F and Y; I, L, V, and M; K and R; N and Q; and S and T. Dashes indicate gaps introduced to maximize alignment.