Table 1.
Baseline characteristics of ASPREE participants for whom MAP was calculated: Overall, and by serious fall that resulted in hospital presentation over the follow-up period
| Characteristic, n | Total ASPREE population (n=16703) | Participants not experiencing a fall (n=15164) | Participants experiencing an incident (first) fall (n=1539) |
|---|---|---|---|
| Age, years | 75.3 (4.4) | 75.1 (4.2) | 77.2 (5.0) |
| Women, n (%) | 9179 (55.0) | 8139 (53.7) | 1040 (67.6) |
| SBP, mmHg | 139.8 (16.3) | 139.8 (16.3) | 139.8 (17.0) |
| DBP, mmHg | 77.2 (10.0) | 77.3 (10.0) | 76.7 (10.1) |
| Alcohol use, n (%) | |||
| Never/Former | 3520 (21.1) | 3159 (20.8) | 361 (23.5) |
| Current | 13183 (78.9) | 12,005 (79.2) | 1178 (76.5) |
| Frailty status | |||
| Not prefrail/frail | 10,292 (61.6) | 9536 (62.9) | 756 (49.2) |
| Prefrail/frail | 6,411 (38.4) | 5628 (37.1) | 783 (50.9) |
| Using antihypertensive medication | 8748 (54.8) | 7876 (54.5) | 872 (58.1) |
| Co-morbidities | |||
| Diabetes | 1644 (9.8) | 1486 (9.8) | 158 (10.3) |
| Chronic renal insufficiency | 2955 (18.2) | 2640 (17.9) | 315 (20.9) |
| Cardiovascular disease* | 488 (3.1) | 393 (2.7) | 95 (6.6) |
| Hospitalisation for heart failure* | 101 (0.6) | 75 (0.5) | 26 (1.7) |
| On Trial medication (Aspirin) | 8322 (49.8) | 7529 (49.7) | 739 (51.5) |
| MAP, mmHg | 98.1 (10.6) | 98.1 (10.6) | 97.7 (10.8) |
| MAP category | |||
| Q1 | 3431 (20.5) | 3105 (20.5) | 326 (21.2) |
| Q2-Q4 | 9994 (59.8) | 9077 (59.9) | 917 (59.6) |
| Q5 | 3278 (19.6) | 2982 (19.7) | 296 (19.2) |
| MAP variability, mmHg (n=14818) | 6.7 (3.9) | 6.7 (3.9) | 7.2 (4.2) |
| MAP variability category (n=14,818) | |||
| T1 | 4948 (33.4) | 4550 (33.7) | 398 (29.9) |
| T2 | 4932 (33.3) | 4490 (33.3) | 442 (33.3) |
| T3 | 4938 (33.3) | 4448 (33.0) | 490 (36.8) |
| Types of antihypertensive medication (n=8748) | |||
| Antiadrenergic | 506 (5.8) | 463 (5.9) | 43 (4.9) |
| Diuretics | 2764 (31.6) | 2453 (31.1) | 311 (35.7) |
| Beta blockers | 734 (8.4) | 639 (8.1) | 95 (10.9) |
| Calcium channel blockers | 1605 (18.4) | 1454 (18.5) | 151 (17.3) |
| Renin angiotensin system inhibitors | 3139 (35.9) | 2867 (36.4) | 272 (31.2) |
*
Before annual visit 2
SBP=Systolic blood pressure, DBP=Diastolic blood pressure, MAP= Mean arterial pressure, Q1=Bottom 20%, Q2-Q4=Middle 60%, Q5=Top 20%, T1=Bottom 33.3%, T2=Middle 33.3%, T3=Top 33.3%