Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 16;92(5):1341–1349. doi: 10.1038/s41390-022-01985-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Oligomycin-induced state 4 was initiated using succinate. Representative tracings of oxygen consumption (above) with simultaneous ΔΨ measurement (below) are depicted (from 3 to 4 biological replicates in each group). Numbers indicate oxygen consumption rates (nmol/mL/min/mg mitochondrial protein). Cyclosporine A (CsA), carboxyatractyloside (cAT), and guanosine diphosphate (GDP) were added to specifically inhibit leak via the mitochondrial permeability transition pore (mPTP), the adenine nucleotide translocase (ANT), and uncoupling proteins (UCPs), respectively. Inhibition of leak was identified by a concomitant decrease in oxygen consumption with a rise or stabilization in ΔΨ. Arrowheads indicate persistent leak despite the obvious closure of a leak channel.