Table 3.

Meta-GWAS results

SNPa	Chr	A1/A2b	Nearby gene(s)c	Meta -pd	Direction	Results for the meta-GWAS SNPs in each individual cohort
						POFC		COHRA1		COHRA2		Dental SCORE
						P	MAF	P	MAF	P	MAF	P	MAF
rs1359694	9	A/C	PTPRD	5.86E–07	––––	0.0245855	0.1223	0.000493	0.1809	0.220907	0.1825	0.002401	0.1825
rs12830414	12	C/T	NAV3	6.07E–07	++++	0.0561199	0.09428	0.006441	0.06867	0.208079	0.07289	4.41 E–05	0.07289
rs682846	19	C/G	MYH14	6.36E–07	––––	0.0304989	0.3097	0.003379	0.4438	0.023739	0.4283	0.009207	0.4283
rs56282801e	12	A/G	DHX37	1.00E–06	––––	0.0004047	0.1984	0.001016	0.2045	0.143019	0.3195	0.135073	0.3195
rs4649222e	1	A/G	KIAA1804	1.83E–06	++++	0.0450894	0.2032	0.003782	0.2803	0.003620	0.2879	0.083122	0.2879
rs2840075	4	C/T	SLC4A4, ENAM	2.20E–06	––––	7.86E–06	0.07779	0.098322	0.1058	0.053585	0.0984	0.156516	0.0984
rs62196465e	20	A/G	MACROD2	2.80E–06	––––	0.0116859	0.05604	0.244040	0.05776	4.20E–05	0.05242	0.112376	0.05242
rs16968212e	15	C/T	SCAPER	2.92E–06	++++	0.2694265	0.06341	0.016560	0.07246	0.014049	0.07978	0.000683	0.07978
rs9846530d	3	C/G	SEMA5B	3.69E–06	––––	0.1448401	0.2127	0.005046	0.2219	2.13E–05	0.2238	0.457281	0.2238
rs7921002	10	G/T	ZMIZ1	4.10E–06	––––	0.0093433	0.3218	0.458316	0.178	0.002012	0.2056	0.005373	0.2056

^aAll the SNPs presented in the table were imputed.

¹ A1 is the effect allele, A2 is the other allele.² Gene within the +500 kb window.³ There is no statistically significant heterogeneity in the meta-analysis results across the cohorts, see supplementary materials, Table S3.⁴ These SNPs were intronic.