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. 2022 Aug 2;16:974393. doi: 10.3389/fnhum.2022.974393

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Copyright © 2022 Wu, Zheng, Hua, Wei, Xue, Li, Xing, Ma, Shan and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Map illustrating brain of multivariate GCA signed-path coefficients alteration after treatment in the immersive-VR group (A) and the control group (B). Some brain regions only showed projection position. Blue/red arrows designate significantly weaken/strengthen of causal connectivity after treatment as compared to baseline levels. MPFC, medial prefrontal cortex; DLPFC, dorsolateral prefrontal cortex; MTG, middle temporal gyrus; pSTS, posterior superior temporal sulcus; INS, insular gyrus; CG, cingulate gyrus; Amyg, amygdala; Hipp, hippocampus; CAU, caudate, Tha, Thalamus. GCA, granger causality analysis.