Items | HCC patients (N = 101) |
---|---|
Demographic characteristics | |
Age (years), mean ± SD | 56.8 ± 11.2 |
Gender, No. (%) | |
Female | 12 (11.9) |
Male | 89 (88.1) |
Disease characteristics | |
HBV, No. (%) | 75 (74.3) |
ECOG PS score, No. (%) | |
0 | 26 (25.7) |
1 | 74 (73.3) |
2 | 1 (1.0) |
Child–Pugh class, No. (%) | |
A | 72 (71.3) |
B | 29 (28.7) |
Extrahepatic metastasis, No. (%) | 56 (55.4) |
Vascular invasion, No. (%) | 42 (41.6) |
BCLC stage, No. (%) | |
B | 29 (28.7) |
C | 72 (71.3) |
CNLC stage, No. (%) | |
Ib | 1 (1.0) |
IIa | 1 (1.0) |
IIb | 16 (15.8) |
IIIa | 26 (25.8) |
IIIb | 56 (55.4) |
UK | 1 (1.0) |
AFP (ng/ml), No. (%) | |
<400 | 57 (56.4) |
≥400 | 39 (38.6) |
UK | 5 (5.0) |
Treatment history | |
Hepatectomy, No. (%) | 27 (26.7) |
Times of previous TACE, No. (%) | |
0 | 29 (28.7) |
1 | 32 (31.7) |
2 | 16 (15.8) |
3 | 7 (6.9) |
>3 | 17 (16.8) |
Refectory to TACE in patients with TACE treatment history, No. (%) | |
No | 26 (25.7) |
Yes | 31 (30.7) |
Previous treatment lines, No. (%) | |
First-line | 82 (81.2) |
Second-line | 17 (16.8) |
> Second-line | 2 (2.0) |
Treatment in the study | |
Times of TACE, No. (%) | |
≤3 | 88 (87.1) |
>3 | 13 (12.9) |
Timing of camrelizumab administration, No. (%) | |
Before TACE | 9 (8.9) |
After TACE | 92 (91.1) |
Treatment cycle of camrelizumab | |
Q2W | 2 (2.0) |
Q3W | 99 (98.0) |
Cycles of camrelizumab, No. (%) | |
≤2 | 12 (11.9) |
3–4 | 33 (32.7) |
>4 | 56 (55.4) |
Interval between TACE and camrelizumab administration, No. (%) | |
Within 7 days | 84 (83.2) |
Within 8 to 14 days | 9 (8.9) |
Within 15 to 28 days | 8 (7.9) |
Treatment regimen, No. (%) | |
Monotherapy of camrelizumab | 53 (52.5) |
Combination therapy with TKI | 48 (47.5) |
Apatinib | 27 (26.7) |
Lenvatinib | 10 (9.9) |
Sorafenib | 4 (4.0) |
Anlotinib | 4 (4.0) |
Regorafenib | 3 (3.0) |
HCC, hepatocellular carcinoma; SD, standard deviation; HBV, hepatitis B virus; ECOG PS, Eastern Cooperative Oncology Group Performance Status; BCLC, Barcelona Clinic Liver Cancer; CNLC, China liver cancer; UK, unknown; AFP, alpha-fetoprotein; TACE, transarterial chemoembolization; Q2W, every 2 weeks; Q3W, every 3 weeks; TKI, tyrosine kinase inhibitors.