Table 2.

Incidence of osteoradionecrosis (ORN) in different studies

Study	Year	Period	Total number of patients	Prevalence of ORN (%)	Mean irradiation dose
Watson and Scarborough20	1938	1930–1937	1,819	12.9
Martin and Sugarbaker21	1940		103	25
MacComb22	1962	1952–1959	251	37.1
MacDougall et al.23	1963		364	5
Grant and Fletcher24	1966	1954–1962	176	37.5	10,000*
Rahn and Drane25	1967	1960–1962	120	44.2
Rankow and Weissman26	1971		176	6.3	5,000*
Wang27	1972		262	5.8
Cheng and Wang28	1974		76	17.1	2,500*
Marciani and Plezia29	1974		220	10.5
Bedwinek et al.30	1976	1966–1971	381	14.2	7,000*
Murray et al.31	1980	1966–1975	653	21.1	5,000*
Morrish et al.19	1981	1971–1977	100	22	7,500*
Epstein et al.32	1987	1977–1984	1,000	2.7	6,000*
Withers et al.33	1995	1976–1985	676	4.7	65†
Turner et al.34	1996	1980–1987	333	5.9	55†
Thorn et al.16	2000	1992–1998	80	74	60†
Storey et al.35	2001	1965–1995	83	6	60†
Reuther et al.36	2003	1969–1999	830	8.2	60†
Oh et al.37	2004	1989–2004	81	4.9	52.6†
Studer et al.38	2004	1980–1998	268	12.5	60†
Ben-David et al.39	2007	1996–2005	176	0	65†
Jham et al.40	2008	2003–2005	207	5.5	58.9†
Katsura et al.41	2008	1996–2003	39	15	60.7†
Gomez et al.42	2009	2000–2006	35	5	60†
Lee et al.43	2009	1990–2000	198	6.6	60†
Stenson et al.44	2010	1994–2008	27	18.4	62†
Gomez et al.45	2011	2000–2007	168	1.2	67.9†
Monnier et al.17	2011	2000–2007	73	40	66†
Crombie et al.46	2012	2000–2007	54	36	69.7†
Niewald et al.47	2013	1993–2001	99	12	72
Tsai et al.48	2013	2000–2008	402	7.5	70†

^*Radiation dose given in rads.

^†Radiation dose given in Grays (Gy).