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. 2022 Aug 2;12:822805. doi: 10.3389/fonc.2022.822805

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Copyright © 2022 Liu, Dai, Wu, Zhang, Yang, Wang, Song, Li, Xia and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Binding of iRGD-Exos to a DLBCL cells in vitro. (A) The blank-Exo or (B) iRGD-Exo were electroporated with BCL6 siRNA1. TEM analysis was used to identify the morphology of exosomes (Scale bar, 100 nm; Red arrow: exosomes). NTA analysis was used to assess the number and size of exosomes. (C, D) The blank-Exo (blank-Exo-siRNA) or iRGD-Exo (iRGD-Exo-siRNA) were electroporated with Cy3-labeled BCL6 siRNA1. OCI-Ly8 cells were treated with Cy3-labeled BCL6 siRNA1 delivered with blank-Exos or iRGD-Exos for 72 h. Representative images were examined by a confocal microscope (Scale bar, 25 μm). (E) RT-qPCR and (F) western blot analysis of BCL6 levels in OCI-Ly8 cells treated with blank-Exo-siRNA and iRGD-Exo-siRNA. **P < 0.01. All tests were repeated in triplicate.