Table 8.

Results of Welch's t-test for the difference in biomarker values between the mild and severe groups defined by the cDTI score for each time point.

Biomarkera	Timepoint	Estimated difference (mild - severe)	SE	df	T-ratio	p-valueb
BDNF	Baseline	−209	561	147	−0.37	0.71
	During TH	248	410	112	0.60	0.55
	End of TH/Rewarming	500	406	111	1.2	0.22
	After Rewarming	−103	468	133	−0.22	0.83
IL-6	Baseline	105	103	148	1.0	0.31
	During TH	−9.6	71	141	−0.14	0.89
	End of TH/Rewarming	−8.7	70	140	−0.13	0.90
	After Rewarming	−19	83	146	−0.23	0.82
VEGF	Baseline	−103	74	129	−1.4	0.17
	During TH	95	60	81	1.6	0.12
	End of TH/Rewarming	131	60	84	2.2	0.033*
	After Rewarming	122	65	102	1.9	0.064
GFAP	Baseline	0.088	0.93	131	0.095	0.92
	During TH	0.48	0.76	89	0.63	0.53
	End of TH/Rewarming	0.31	0.76	87	0.41	0.69
	After Rewarming	0.55	0.84	110	0.66	0.51
NRGN	Baseline	0.019	0.16	139	0.12	0.91
	During TH	−0.010	0.13	98	−0.077	0.94
	End of TH/Rewarming	0.12	0.13	96	0.89	0.38
	After Rewarming	0.13	0.15	120	0.86	0.39
IL-10	Baseline	−124	15	120	−8.3	1.5 ×10−13***
	During TH	−11	11	120	−1.0	0.30
	End of TH/Rewarming	0.013	11	120	0.0012	1.0
	After Rewarming	−0.49	13	120	−0.039	0.97
IL-8	Baseline	46	128	118	0.36	0.72
	During TH	59	96	92	0.61	0.54
	End of TH/Rewarming	58	98	94	0.59	0.56
	After Rewarming	−18	111	109	−0.16	0.88
Tau	Baseline	−50	310	140	−0.16	0.87
	During TH	−276	225	112	−1.2	0.22
	End of TH/Rewarming	−461	217	107	−2.1	0.036*
	After Rewarming	−808	250	126	−3.2	0.0015**

^aBiomarkers with significant differences between the severe and mild groups are made bold.

^b*p < 0.05, **p < 0.01, and ***p < 0.001.