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. 2022 Aug 2;13:939127. doi: 10.3389/fimmu.2022.939127

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Copyright © 2022 Chen, Zhang, Zhu, An, Jiang, Yang, Ma, Yang and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4⁺ T-cell subsets and cytokines expression. (A) Manual gating strategy for CD4⁺ T-cell subsets and representative plots for Th1 (CD3⁺CD4⁺CXCR3⁺), Th2 (CD3⁺CD4⁺CRTH2⁺), Tfh (CD3⁺CD4⁺CXCR5⁺PD-1⁺), and Treg (CD3⁺CD4⁺CD25⁺CD127^low/−). IFN-γ⁺Th1, IL-4⁺ Th2, IL-13⁺ Th2, IL-13⁺ Tfh, and IL-10⁺ Treg were representatively exhibited and compared with FMO control. (B) The dot plot figures showed CD4⁺ T-cell subsets; (C) the cytokines of the Th1 (IFN-γ), Th2 (IL-4 and IL-13), Tfh (IL-13), and Treg (IL-10). ABPA, allergic bronchopulmonary aspergillosis; A.f (+) asthma, Aspergillus fumigatus-sensitized asthma; HDM (+) asthma, house dust mite-sensitized asthma; Th1, T helper cells 1; Th2, T helper cells 2; Tfh, follicular helper T cells; Treg, regulatory T cells; IFN-γ, interferon γ; IL-4, interleukin 4; IL-13, interleukin 13; IL-10, interleukin 10. *p<0.05, **p<0.01; ***p<0.001.