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. 2022 Aug 2;13:929442. doi: 10.3389/fphar.2022.929442

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Copyright © 2022 Mumu, Das, Emran, Mitra, Islam, Roy, Karim, Das, Park, Chandran, Sharma, Khandaker, Idris and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antiobesity effects of FX through regulating lipid metabolism: FX significantly reduces free fatty acid synthesis via controlling many enzymes, which are associated with lipid metabolism. It promotes β-oxidation, bile acid synthesis pathway, and Sirt1/AMPK pathway and inhibits lipogenesis, mevalonate pathway, pentose phosphate pathway, and glycerol phosphate pathway. As a result, plasmatic and hepatic triglyceride and cholesterol concentrations are decreased. It reduces lipid accumulation in hepatic cells and adipose tissues.