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. 2022 Jul 8;6:246. Originally published 2021 Sep 24. [Version 3] doi: 10.12688/wellcomeopenres.17202.3

Figure 2. Concentration-time profiles of efavirenz in cervicovaginal fluid collected with flocked swabs and plasma.

Figure 2.

The median (range) cervicovaginal swab (CVS) efavirenz AUC 0-24h estimated from the pooled data (n = 5) was 16370 ng*h/mL (5803-22088), C max was 1618 ng/mL (610-2438) at a T max of 8.0 h (8.0-12), and C min was 399 ng/mL (110-981). Efavirenz CVS:plasma AUC 0-24h ratio was 0.41 (0.20-0.59). Efavirenz C min in CVS was above the protein binding adjusted IC 95 for wild-type HIV-1 of 126 ng/mL (lower dashed lines) in all five patients and but below the 470 ng/mL (upper dashed lines) trough plasma effective concentration threshold established in the ENCORE 1 study in three out of five patients.