Table 4. Stability of ceftriaxone in plasma under different conditions.
Due to the recovery difference between anticoagulants, EDTA, Na-heparin and Li-heparin are compared to the average concentration of the four precision and accuracy batches for each anticoagulant and are presented as percentages.
| QC1, 2.97 µg/ml | RT 24 hrs | RT 48 hrs | 4°C 24 hrs | 4°C 48 hrs | F/T cycle 3 | F/T cycle 5 | Precipitated 4hrs in RT | -80°C
224 days |
|---|---|---|---|---|---|---|---|---|
| CPD | 106 | 100 | 102 | 103 | 97.7 | 94.0 | 94.2 | 103 |
| CPD haemolysis | - | - | - | - | - | 88.4 | 99.3 | - |
| EDTA | 105 | - | 113 | - | 103 | 103 | 98.0 | 95.5 |
| Na-Hep | 103 | - | 109 | - | 100 | 98.7 | 96.8 | 93.7 |
| Na-Hep haemolysis | - | - | - | - | 91.3 | 97.6 | 91.9 | - |
| Li-Hep | 105 | - | 98.3 | - | 95.7 | 99.5 | 103 | 96.0 |
| QC3, 155 µg/ml | RT 24 hrs | RT 48 hrs | 4°C 24 hrs | 4°C 48 hrs | F/T cycle 3 | F/T cycle 5 | Precipitated 4hrs in RT | -80°C
224 days |
| CPD | 99.8 | 99.6 | 101 | 103 | 99.1 | 95.0 | 101 | 109 |
| CPD haemolysis | - | - | - | - | - | 98.6 | 94.3 | - |
| EDTA | 105 | - | 104 | - | 97.9 | 95.5 | 90.9 | 92.8 |
| Na-Hep | 103 | - | 106 | - | 97.5 | 93.7 | 88.2 | 94.5 |
| Na-Hep haemolysis | - | - | - | - | 90.4 | 88.5 | 88.8 | - |
| Li-Hep | 101 | - | 108 | - | 96.1 | 94.2 | 91.4 | 98.8 |
Hep, heparin; RT, ambient room temperature (about 23°C), F/T, freeze and thaw, “-“, not available.