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. 2022 Jun 22;82(16):2848–2859. doi: 10.1158/0008-5472.CAN-21-3552

Figure 2.

Figure 2. Differences in the prostate cancer AR cistrome between AA and EA men associate with distinct RNA expression programs. A, Unsupervised pairwise correlation of the AR cistromes from AA and EA prostate tumors. Hierarchical clustering demonstrates the relatedness of each AR cistrome. B, Volcano plot of ancestry-enriched ARBS. 16,678 ARBS were enriched in AA relative to EA (AA-ARBS) prostate tumors and 1,655 ARBS in EA relative to AA prostate tumors (EA-ARBS) with an FDR-adjusted P < 0.01 and log2 fold change > 1. C, Differential gene expression analysis of 30 AA and 19 EA paired tumor-normal prostate specimens. 466 genes were upregulated in AA and 729 genes were upregulated in EA prostate tumors with an FDR-adjusted P < 0.05 and log2 fold change > 1.5. D, GSEA of AA-ARBS are enriched for genes upregulated in AA relative to EA prostate tumors (NES = 1.96; P < 0.001). E, GSEA of genes upregulated in AA prostate tumors are enriched for AA-ARBS (NES = 2.04; P < 0.001). ES, enrichment score.

Differences in the prostate cancer AR cistrome between AA and EA men associate with distinct RNA expression programs. A, Unsupervised pairwise correlation of the AR cistromes from AA and EA prostate tumors. Hierarchical clustering demonstrates the relatedness of each AR cistrome. B, Volcano plot of ancestry-enriched ARBS. The 16,678 ARBS were enriched in AA relative to EA (AA-ARBS) prostate tumors and 1,655 ARBS in EA relative to AA prostate tumors (EA-ARBS) with an FDR-adjusted P < 0.01 and log2-fold change > 1. C, Differential gene expression analysis of 30 AA and 19 EA paired tumor-normal prostate specimens. The 466 genes were upregulated in AA and 729 genes were upregulated in EA prostate tumors with an FDR-adjusted P < 0.05 and log2-fold change > 1.5. D, GSEA of AA-ARBS are enriched for genes upregulated in AA relative to EA prostate tumors (NES = 1.96; P < 0.001). E, GSEA of genes upregulated in AA prostate tumors are enriched for AA-ARBS (NES = 2.04; P < 0.001). ES, enrichment score.