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. 2022 Jun 22;82(16):2848–2859. doi: 10.1158/0008-5472.CAN-21-3552

Figure 3.

Figure 3. The AR prostate cancer cistrome associates with lipid metabolism, immune response, and cytokine signaling. A, Three most significantly enriched nucleotide motifs present in AA-ARBS and EA-ARBS by de novo motif analysis. B, Pathway enrichment of the AA-ARBS identified using CISTROME-GO (23). AR binding intensity in each AA and EA prostate tumor for Hallmark lipid metabolism (C) and immune response and cytokine signaling (E) gene sets using ssGSEA analysis (24). Differential expression analysis in our RNA-seq data identifies upregulation of Hallmark lipid metabolism (D) and immune response and cytokine signaling (F) gene sets in AA (n = 30) versus EA (n = 19) prostate tumors. G, Estimation of tumor infiltrate immune populations demonstrates greater signal for B cells (P = 0.01) and macrophages (P = 0.003), and a trend towards CD8+ T cells (P = 0.051) in AA versus EA prostate cancer (41). NK, natural killer.

The AR prostate cancer cistrome associates with lipid metabolism, immune response, and cytokine signaling. A, Three most significantly enriched nucleotide motifs present in AA-ARBS and EA-ARBS by de novo motif analysis. B, Pathway enrichment of the AA-ARBS identified using CISTROME-GO (23). C and E, AR binding intensity in each AA and EA prostate tumor for Hallmark lipid metabolism (C) and immune response and cytokine signaling (E) gene sets using ssGSEA analysis (24). D and F, Differential expression analysis in our RNA-seq data identifies upregulation of Hallmark lipid metabolism (D) and immune response and cytokine signaling (F) gene sets in AA (n = 30) versus EA (n = 19) prostate tumors. G, Estimation of tumor infiltrate immune populations demonstrates greater signal for B cells (P = 0.01) and macrophages (P = 0.003), and a trend towards CD8+ T cells (P = 0.051) in AA versus EA prostate cancer (41). NK, natural killer.