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. 2022 Jun 22;82(16):2848–2859. doi: 10.1158/0008-5472.CAN-21-3552

Figure 5.

Figure 5. Upregulated lipid metabolism is associated with worse prostate cancer outcomes. Kaplan–Meier survival curves for time to treatment failure (A) and OS (B) on abiraterone or enzalutamide for 81 men with metastatic castration-resistant prostate cancer based on lipid metabolism activity (36). Lipid metabolism scores were generated by applying ssGSEA to normalized RNA-seq data and extracting sample-level enrichment scores for the Hallmark Fatty Acid Metabolism gene set. Outcomes were compared between men in the top quartile versus the lower three quartiles based on ssGSEA enrichment scores.

Upregulated lipid metabolism is associated with worse prostate cancer outcomes. Kaplan–Meier survival curves for time to treatment failure (A) and OS (B) on abiraterone or enzalutamide for 81 men with metastatic castration-resistant prostate cancer based on lipid metabolism activity (36). Lipid metabolism scores were generated by applying ssGSEA to normalized RNA-seq data and extracting sample-level enrichment scores for the Hallmark Fatty Acid Metabolism gene set. Outcomes were compared between men in the top quartile versus the lower three quartiles based on ssGSEA enrichment scores.