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. 2022 Jul 25;18(13):4932–4949. doi: 10.7150/ijbs.76425

Figure 1.

Figure 1

CPNE8 was overexpressed in gastric cancer and associated with poor patient survival. (A) Venn diagram showing genes with high expression and association with tumor metastasis in the TCGA-STAD cohort. (B) Comparison of CPNE8 gene expression between 375 tumor tissues and 32 normal tissues. (C) Normalized GEO data demonstrating differential expression of CPNE8 gene between 15 tumor tissues and paired normal tissues. (D) Increasing CPNE8 expression in metastatic gastric cancer compared to primary tumors. (E) The area under the ROC curve (AUC) indicated that CPNE8 revealed better efficiency in predicting metastatic gastric cancer. (F) Significantly different expression of CPNE8 among tumor stages in the TCGA-STAD cohort. (G) Significantly different expression of CPNE8 among tumor grades in the TCGA-STAD cohort. (H) Overall survival (OS) curves based on CPNE8 status. (I) Progression-free survival (PFS) curves based on CPNE8 status. (J) Disease-free survival (DFS) curves based on CPNE8 expression. (K) The representative microscopy images of CPNE8 in normal tissue and gastric cancer tissue were shown at 100X and 200X magnifications. (L) The IHC scores displayed that CPNE8 was upregulated in most GC than normal tissue. (M) The overall survival curve was based on CPNE8 scores obtained by immunohistochemistry.