Figure 3.

CPNE8 promoted GC cell migration and invasion in vitro. (A) Wound-healing assays revealed that stably suppressed CPNE8 expression inhibited migration of GC cells in vitro, whereas elevated CPNE8 expression had the opposite effects. (B) Quantitative analysis of wound closure. (C) Transwell assays showed that knockdown of CPNE8 reduced the migration and invasion of GC cells while overexpression of CPNE8 enhanced the migration and invasion ability of the GC cells. (D) Quantitative analysis of migration and invasion of GC cells. Data are presented as mean values ± SD of three independent experiments.