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. 2022 Jul 25;18(13):4932–4949. doi: 10.7150/ijbs.76425

Figure 6.

Figure 6

High expression of CPNE8 was associated with the infiltration of cancer-associated fibroblasts in GC. (A) Manipulated Stromal score, Immune score, and ESTIMATE score based on CPNE8 status in TCGA-STAD cohort. (B) The correlation of CPNE8 expression and the infiltration of CAFs was quantified using the TIDE, EPIC, and XCELL algorithm in the TCGA-STAD cohort in the TIMER2 database. Each dot represents one sample. (C) Immunohistochemistry staining of CPNE8 and a-SMA in GC tissues of xenograft mice. (D) Significant and positive correlations between CPNE8 expression and ACTA2, FAP, ITGB1, PDPN, S100A4, and THY1. (E) The correlation of CPNE8 expression with various chemokines or chemokine receptors was displayed using the TISIDB database. (F) The mRNA levels of chemokine receptors were quantified by qRT-PCR in GC cells with respective knockdown or overexpression of CPNE8 compared to the control cells.