Figure 7.

CPNE8 expression could predict the clinical benefit of ICB. (A) Correlation of CPNE8 expression and immune infiltrating cells quantified using the MCP-counter algorithm in the TCGA-STAD cohort. (B) Correlation between ssGSEA scores of 29 immune cells and CPNE8 expression in gastric cancer. (C) The heatmap showed the correlation between CPNE8 expression and immune checkpoint genes. G1 represented the CPNE8 high expression group; G2 represented the CPNE8 low expression group. (D) Increased CPNE8 expression was associated with higher immune dysfunction scores. (E) The mRNA expression of CPNE8 was positively correlated with the TIDE score. (F) The rate of immune checkpoint blockade responses in GC patients was predicted by the TIDE algorithm in the high or low CPNE8 groups.