Table 2.
Review of siRNA-based patents issued or under consideration for Coronaviruses
| Patent number | Target region | Virus | Year |
|---|---|---|---|
| CN1458281 | RdRP, S protein, M protein,packaging protein | SARS-CoV | 2003 |
| CN1465584 | various | SARS-CoV | 2003 |
| CN1548054 | RdRP (RNA polymerase) | SARS-CoV | 2003 |
| CN1569233 | RdRp, helicase, nucleoprotein N, proteolytic enzyme gene | SARS-CoV | 2003 |
| CN1569878 | target sequence in the patent | SARS-CoV | 2003 |
| CN1590545 | RdRp, S protein, M gene, UP4, UP5, N | SARS-CoV | 2003 |
| CN1609116 | replicase polymerase guide region | SARS-CoV | 2003 |
| CN1609117 | replicase polymerase guide region | SARS-CoV | 2003 |
| US20030224353 | ORF1 | SARS-CoV | 2003 |
| CN1648249 | M, N, E gene | SARS-CoV | 2004 |
| US20050020525 | various | SARS-CoV | 2005 |
| JP2006238724 | various | SARS-CoV | 2005 |
| WO2005019410 | Nsp-1, Nsp-9, S protein | SARS-CoV | 2005 |
| CN101085986 | ORF3a | SARS-CoV | 2006 |
| CN101113158 | RdRP (RNA polymerase) | SARS-CoV | 2006 |
| CN101173275 | M1 and M2 gene | SARS-CoV | 2006 |
| EP1482037 | replicase (Pol) region | SARS-CoV | 2006 |
| US20050004063 | replicase A1, S, N, M, E gene | SARS-CoV | 2006 |
| WO200409238 | NC_004718 | SARS-CoV | 2007 |
| US20070270360 | NC_004718 | SARS-CoV | 2007 |
| CN101182517 | S, Nsp-9, Nsp-10, Nsp-13, E, M, N proteins | SARS-CoV | 2007 |
| JP2008253188 | DNaseX | SARS-CoV | 2007 |
| CN102453712 | PI4KB, PI4KA | SARS-CoV | 2010 |
| US20040192626 | various | SARS-CoV | 2012 |
| US8653252 | Replicase (Pol) region;pS3Xs (pGL3 with SARS sense, antisense target) and one without SARS target | SARS-CoV | 2014 |
| CN107488660 | ORF3 25962 25983bp of GenBank DQ497008 | SARS-CoV | 2017 |
| WO2017044507 | P.L. pro, RdRp, S protein | MERS-CoV | 2019 |
| WO2005023083 | various | SARS-CoV-2 | 2020 |