Figure 5.

Silencing of circARID1A significantly retarded GBM growth in vivo. A. Images of intracranial glioma xenograft in BALB/c-nu after injection of D-luciferin using in-vivo imaging system. B. Results showing that the growth rate was significantly decreased in group sh-circARIDIA compared with group shNC. n =5 *p < 0.05, ANOVA. C. Images of tumor harvested in day 15. D. Tumor weights in group sh-circARID1A were significantly decreased compared to weight in group shNC. n = 5, *p < 0.05, t-test. E, F. Immunohistochemistry Images showing that the expression of TGFBR2 markedly decreased when circARID1A was silenced, n = 5, *p < 0.05, ANOVA