Figure 3.

Role of LLPS in oncogenic signaling. (A). In Wnt/β-catenin signaling pathway, Axin, and APC assemble into a destruction complex condensate that recruits other members such as GSK3 and CKI. β-catenin accumulates and is transported to the nucleus, where it may localize to condensates at super-enhancers to activate the expression of target genes. (B). YAP/TAZ condensates co-localize with TEAD and recruit RNA Pol II to promote the expression of downstream target gene. (C). TGF-β promotes the expression of DACT1, which through LLPS is required for compartmentalising hundreds of proteins including CK2.