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Role of LLPS in autophagy. (A). p62 interaction with NBR1 proteins and bind to ubiquitin and the polyubiquitin chains of autophagy receptor OPTN to form autophagy receptor condensates; (B). ULK1 complex contains FIP200, ATG13, ULK1 and ATG101. ATG13 interact with FIP200 by the IDR domains multivalent interactions and thus drive LLPS of the ULK1 complex to recruit downstream autophagy proteins for autophagosome formation.
