Figure 6.

Role of LLPS in tumor virus-associated proteins. (A). EBNA2 and EBNALP recruit other coactivators and transcription factors forming phase-separated condensates at enhancer sites to drive gene activation. These are driven in part by the interactions of IDRs. (B). LANA-associated nuclear bodies structures self-assembly through LLPS to build dynamic structures. DAXX is a component of the latent phase LANA-associated nuclear bodies, and the low complexity, multivalent N-terminal domain interactions driving LLPS.