Table 1.

Endpoints

Primary end point	Change in left ventricular peak filling rate (ΔLVPFR)
Secondary endpoints	Change in left atrial passive emptying fraction (ΔLAPEF) Change in left ventricular ejection fraction (ΔLVEF)
Explorative endpoints include	Cardiovascular: Change in oxygen consumption max and exercise tolerance test variables Change in central blood volume and haematocrite Change in heart rate variability Change in left ventricular volume Metabolic: Basal and postprandial AUC free fatty acids and glycerol turnover Endogenous glucose production and tissue glucose disposal (metabolic clearance of glucose) Fasting and postprandial energy expenditure and respiratory quotient Glucagon–insulin ratio Insulin sensitivity (AUC glucose metabolic clearance/AUC insulin concentration) Beta-cell function (prehepatic insulin secretion rate, correlated to ambient glucose)

AUC, area under the curve.