Figure 1. Overview of HCV IRES‐mediated initiation complexes.

• A
  Secondary structure of the HCV IRES, annotated to show individual elements.
• B
  Segmented maps of the indicated ribosomal complexes assembled on the wt or ΔdII HCV IRES, showing the 40S subunit (yellow), IRES (red), eIF1A (blue), Met‐tRNA_i ^Met (magenta), and initiation factors eIF2 (green) or eIF5B (cyan).