Figure EV1. All HCV IRES‐mediated initiation complexes.

• A
  Segmented maps of the indicated 40S ribosomal complexes assembled on the wt or ΔdII HCV IRES, showing the 40S subunit (yellow), IRES (red), eIF1A (blue), Met‐tRNA_i ^Met (magenta), and initiation factors eIF2 (green) or eIF5B (cyan). Complexes assembled on the wt or ΔdII HCV IRES that share identical 40S subunit conformation and factor composition are enclosed by dashed lines.
• B
  Interaction between the IRES and the 40S subunit at different stages of initiation. Contacts with ribosomal proteins (red) and 18S rRNA (yellow), and the AUG codon (blue) are marked for the indicated complexes. See Appendix Table S4 for additional information.