Figure 2.

NMN prevented oxidative damage and alleviated lung injury in endotoxemia mice. (a) The Kaplan–Meier survival curve for NMN pretreated mice and PBS pretreated mice after LPS administration. n = 15 for the control group, n = 18 for the LPS group, n = 16 for the LPS + NMN group, ^#p < 0.05, *p < 0.01. (b) HE staining and corresponding lung histology scores. Scale bar, 100 μm. (c) ROS levels. (d) MnSOD activity. Statistical difference was calculated by one-way ANOVA (n = 5/group). (e) Representative TUNEL staining of formalin-fixed lung sections. Scale bar, 100 μm and (f) counted percentages of TUNEL-positive cells (n = 3/group, Power calculation for statistic differences between groups = 1). (A color version of this figure is available in the online journal.)