Table 2.
Association of Kawanet-score, initial echocardiography findings, and their combination with treatment failure, N=363.
| Need for second-line treatment |
Persistent fever at H48 |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Yes, N=57/363 (16%) | No, N=306/363 (84%) | Univariate analysis |
Multivariate analysisc |
Yes, N=81/363 (22%) | No, N=282/363 (78%) | Univariate analysis |
Multivariate analysisc |
||||
| OR [95% CI] | P value | OR [95% CI] | P value | OR [95% CI] | P value | OR [95% CI] | P value | |||||
| Kawanet scoreb (NA=23) | 23/53 (43%) | 78/287 (27%) | 2.1 [1.2; 3.7] | 0.019 | 2.2 [1.1; 4.3] | 0.021 | 32/77 (42%) | 69/263 (26%) | 2.0 [1.2; 3.4] | 0.010 | 2.3 [1.3; 4.2] | 0.007 |
| Baseline coronary artery maximal Z-score ≥ 2.0 | 29/57 (51%) | 60/306 (20%) | 4.2 [2.4; 7.7] | <0.0001 | 5.6 [2.9; 11.1] | <0.0001 | 30/81 (37%) | 59/282 21%) | 2.2 [1.3; 3.8] | 0.003 | 3.0 [1.7; 5.5] | 0.0003 |
| Abnormal initial echocardiography (NA=4)a | 34/57 (60%) | 77/302 (25%) | 4.4 [2.5; 8.0] | <0.0001 | 5.7 [3.0; 11.2] | 0.0001 | 38/81 (47% | 73/278 (26%) | 2.5 [1.5; 4.2] | 0.0004 | 3.1 [1.8; 5.5] | 0.0001 |
a
Defined as initial maximal Z-score ≥ 2, pericarditis, myocarditis, or ventricular dysfunction.
b
With a threshold ≥ 2.
c
Adjusted on age, sex, ethnicity, complete Kawasaki disease, year of diagnosis, and delay between disease onset and first-line treatment.