Table 1: Proportion of HFpEF (out of Total Heart Failure Cases) in Community-based Studies and Registries.
| Study | Year Published | Years Conducted | Population Source | HFpEF Definition | Proportion of HFpEF (%) |
|---|---|---|---|---|---|
| Devereux et al.[16] | 2000 | 1993–1995 | Participants of Strong Heart Study | LVEF ≥55% | 53 (50/95) |
| Philbin et al.[17] | 2000 | 1995 and 1997 | Hospitalised patients for HF in 10 acute care community hospitals in New York, US | LVEF >50% | 24 (312/1,291) |
| Gottdiener et al.[18] | 2002 | 1989–1993 | Participants of Cardiovascular Health Study | LVEF ≥55% | 22 (60/269) |
| MacCarthy et al.[19] | 2003 | 1993–1995 | Participants of UK-HEART study | LVEF ≥50% | 31 (163/522) |
| Gustafsson et al.[20] | 2003 | 1993–1996 | Participants of DIAMOND-CHF | WMI >1.6 | 40 (2,218/5,491) |
| Redfield et al.[21] | 2003 | 1997–2000 | Randomly selected residents of Olmsted County, MN, US | LVEF ≥50% | 44 (20/45) |
| Lenzen et al.[22] | 2004 | 2000–2001 | Participants of EuroHeart Failure Survey | LVEF ≥40% | 46 (3,148/6,806) |
| Owan et al.[23] | 2005 | 1987–2001 | Hospitalised patients for decompensated HF at Mayo Clinic Hospitals in Olmsted County, Minnesota, US | LVEF ≥50% | 47 (2,167/4,596) |
| Bhatia et al.[24] | 2006 | 1999–2001 | Patients with HF admitted to 103 hospitals in Ontario, Canada | LVEF >50% | 31 (880/2,802) |
| Yancy et al.[25] | 2006 | 2001–2004 | Participants of ADHERE hospitalisation database | LVEF ≥40% | 50 (26,322/52,187) |
| Bursi et al.[26] | 2006 | 2003–2005 | Residents of Olmsted County, MN, US with incident or prevalent HF | LVEF ≥50% | 55 (308/556) |
| Gheorghiade et al.[27] | 2007 | 2003–2004 | Participants of OPTIMIZE-HF | LVEF ≥40% | 51 (21,149/41,276) |
| Lee et al.[28] | 2009 | 1981–2004 | Participants of Framingham Heart Study | LVEF >45% | 41 (220/534) |
| Ho et al.[29] | 2013 | 1981–2008 | Participants of Framingham Heart Study | LVEF >45% | 43* (196/457) |
| Gurwitz et al.[30] | 2013 | 2005–2008 | Patients with newly diagnosed HF from four sites from Cardiovascular Research Network | LVEF ≥50% | 52* (6,210/11,994) |
| Brouwers et al.[31] | 2013 | 1997–2010 | Participants of PREVEND study | LVEF ≥50% | 34* (125/374) |
| Cheng et al.[32] | 2014 | 2005–2011 | Participants of GWTG-HF registry | LVEF ≥50% | 47 (18,897/40,239) |
| Gerber et al.[33] | 2015 | 2000–2010 | Residents of Olmsted County, MN, US | LVEF ≥50% | 53* (1,089/2,074) |
| Alehagen et al.[34] | 2015 | 2000–2012 | Participants of Swedish Heart Failure Registry | LVEF ≥50% | 19 (9,140/46,959) |
| Ho et al.[35] | 2016 | 1979–2002 | Pooled data of four community-based cohorts (Framingham Heart Study, Cardiovascular Health Study, PREVEND, MESA) | LVEF >45% | 48* (909/1,891) |
*Based on incident rates. HF = heart failure; HFpEF = heart failure with preserved ejection fraction; LVEF = left ventricular ejection fraction; WMI = wall motion index. Adapted from Dunlay et al. 2017.[81] Used with permission from: Nature Publishing Group.