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(A) Structures of lipid II found in vancomycin-sensitive and -resistant strains. Features specific to bacterial species and associated resistance are indicated. (B) Binding of vancomycin to d-Ala-d-Ala via hydrogen bonding (dotted lines). Target modification to d-Ala-d-Lac in vancomycin-resistant strains results in loss of one hydrogen bond (indicated in blue).
