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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Neurogastroenterol Motil. 2021 Mar 15;33(10):e14118. doi: 10.1111/nmo.14118

TABLE 1.

Quality indicators deemed to be valid by consensus opinion from 17 experts using two-round Delphi technique.

Quality Indicator Agreement (%)
Importance Scientific Acceptability Usability Feasibility
IF a patient has dysphagia in the context of suspected achalasia, THEN an endoscopy with esophageal biopsies should be performed to rule out mechanical obstruction or eosinophilic esophagitis. 94.1 88.2 94.1 94.1
IF symptoms of GERD occur after achalasia treatment, THEN the patient should be treated with an anti-reflux regimen. 93.3 93.3 100 100
IF a patient with esophageal dysphagia has an endoscopy with esophageal biopsies and the results are unrevealing THEN high- resolution stationary esophageal manometry should be pursued. 93.8 93.8 93.8 93.8
If manometry is performed, THEN high-resolution technology should be used. 93.8 100 100 87.5
IF high-resolution manometry is performed, THEN the Chicago classification v3.0 should be used to help define clinically relevant phenotypes using a standardized language. 93.8 93.8 93.8 100
IF a patient is diagnosed with achalasia, THEN the patient should be educated on all treatment options with a discussion on risk and benefits. 100 100 93.8 87.5
IF myotomy (surgical or endoscopic) is performed in achalasia, THEN patients should be made aware of the potential risk of developing gastroesophageal reflux disease (GERD) following myotomy. 100 100.0 100 93.8
IF a patient diagnosed with achalasia undergoes laparoscopic surgical myotomy, THEN concomitant partial fundoplication can be performed. 93.8 93.8 100 100
IF a patient with a diagnosis of achalasia is healthy THEN Botox should not be offered as a long-term treatment option. 100 93.8 93.8 87.5
IF a patient is diagnosed with achalasia and is high risk for surgery or has a short life expectancy, THEN Botox can be considered. 93.8 87.5 87.5 93.8
IF symptoms due to achalasia return after achalasia treatment, THEN an objective re-evaluation should be completed. 100.0 100 100 100
IF a patient diagnosed with achalasia responds to a form of treatment and has recurrent symptoms, THEN the patient will likely need additional endoscopic or surgical therapies in the future. 93.8 93.8 87.5 87.5