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. 2022 Jul 14;9(8):1241–1251. doi: 10.1002/acn3.51625

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Correlogram of biomarkers in CSF of untreated adults with SMA at baseline. The correlogram shows the spearman's rho correlation coefficient and accompanying p‐values between all four biomarkers in CSF of untreated adults with SMA at baseline. We observed a strong correlation between YKL‐40 and neurofilaments in CSF, as well as between the neurofilaments in CSF. CHIT1 did not correlate with any of the other biomarkers. *Denotes a significant p‐value. Abbreviations: CHIT1, chitotriosidase‐1; YKL‐40, chitinase‐3‐like protein 1; CSF, cerebrospinal fluid; pNfH, phosphorylated neurofilament heavy chain; NfL, neurofilament light chain.