Figure 2.

Graph plot of growth measurements of probands with ANKLE2 variants. Available OFC (A) and stature (B) measurements at birth and subsequent clinical evaluations are plotted with the age in months on the x‐axis and z‐scores on the y‐axis. Most affected probands had congenital microcephaly (OFC z‐scores ≤ −2) and all probands for whom postnatal OFC measurements were available had severe microcephaly (OFC z‐scores ≤ −3). Microcephaly was notably progressive in nature in all affected probands. OFC, occipitofrontal circumference. [Colour figure can be viewed at wileyonlinelibrary.com]