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. 2022 Jul 28;9(8):1186–1194. doi: 10.1002/acn3.51618

Figure 1.

Figure 1

ATXN1 is hypo‐methylated in B cells upon MS. The boxplots represent mean methylation levels at four differentially methylated regions within ATXN1 genomic sequence (DMR1, chr6:16640696–16641053; DMR2, chr6:16473394–16473577; DMR3, chr6:16420309–16422015; DMR4, chr6:16306158–16306782) in four relevant immune peripheral cytotypes (CD4+ and CD8+ T cells, CD19+ B cells, and CD14+ monocytes) between untreated MS patients (N = 17 for T cells, N = 29 for B cells, N = 12 for monocytes) and healthy controls (N = 12 for T cells, N = 24 for B cells, N = 10 for monocytes). Differences between MS patients and controls in each cell type were assessed by Mann–Whitney U test. *p < 0.05, ***p < 0.001.