Figure 7.

Daily GBZ 4.5 mg/kg regionally ameliorates myelin pathology the corpus callosum in 2b4 ^he 2b5 ^ho mice. WT and 2b4 ^he 2b5 ^ho (VWM) mice were injected daily with placebo, 4.5 mg/kg S1 (S1 D4.5), 4.5 mg/kg GBZ (GBZ D4.5) or weekly with 10 mg/kg GBZ (GBZ W10). Sagittally cut brain sections of 2 WT and 2 VWM mice were stained for MOG (brown) and counter stained with H&E (purple, indicating nuclei). Images show representative stainings of indicated sections per indicated treatment. Images are from the same section and represent one mouse per condition. White bars, 50 μm. [Colour figure can be viewed at wileyonlinelibrary.com]