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. 2022 Jul 15;5(8):625–641. doi: 10.1021/acsptsci.2c00076

Figure 4.

Figure 4

[35S]GTPγS binding assays with the quinoline series of derivatives and membranes prepared from HEK293 cells expressing the human A3AR. Concentration–response curves with Cl-IB-MECA were conducted in the presence of vehicle or 0.1, 1.0, or 10 μM modulator compounds. Results were normalized to the Emax value obtained in the presence of vehicle. Data are presented as mean ± SEM; n = 3. * p < 0.05 vs vehicle by one-way ANOVA followed by Bonferroni-adjusted t tests for post hoc comparison. EC50 and Emax values are reported in Table S3.