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. 2022 Jul 15;5(8):625–641. doi: 10.1021/acsptsci.2c00076

Figure 7.

Figure 7

Characterization of human/mouse chimeric A3ARs. (A, C) [35S]GTPγS binding assays with Cl-IB-MECA (agonist) and either compound 4 (A) or compound 1 (C). (B) [125I]I-AB-MECA dissociation binding assays in the presence of vehicle or 10 μM compound 4. (D, E) [125I]I-AB- MECA equilibrium binding assays in the presence of increasing concentrations of compound 1 (D) or compound 4 (E). EC50 and Emax values from the [35S]GTPγS binding assays and values for the [125l]l-AB-MECA dissociation binding assays are presented in Table S5.